Platform Leadership

Raymond Lam, MD, FRCPC
Roumen Milev, MD, PhD, FRCPC

Active Sites

The Clinical Outcomes Platform operates at the following research sites:

  • Centre for Addiction and Mental Health (Toronto, Ontario)
  • Dalhousie University (Halifax, Nova Scotia)
  • Queen’s University (Kingston, Ontario)
  • St. Joseph’s Healthcare Hamilton (Hamilton, Ontario)
  • St. Michael’s Hospital (Toronto, Ontario)
  • University of British Columbia (Vancouver, British Columbia)
  • University of Calgary (Calgary, Alberta)
  • University Health Network (Toronto, Ontario)

Platform Overview

The Clinical Platform is responsible for developing study protocols and ensuring the highest safety standards for study participants. This includes determining the most appropriate study population, study design and clinical assessments for each study. The Clinical team ensures clinical studies are carried out in accordance with the developed study protocols, Good Clinical Practice (GCP) as defined by the International Conference on Harmonization (ICH), the principles of the Declaration of Helsinki, and with local regulations. The Clinical Platform uses a comprehensive range of clinical interviews and self-reports to collect clinical outcome measures. These tools assess dimensions of mood, anxiety, circadian rhythms, personality, life experiences, cognition, functional outcomes, and other dimensions as required by each study.


Resources and Publications

Publication on Personality

Allen, T. A., Carey, B. E., Mcbride, C., Bagby, R. M., Deyoung, C. G., & Quilty, L. C. (2017). Big Five aspects of personality interact to predict depression. Journal of Personality. doi:10.1111/jopy.12352
(Abstract here)

Publication on the BRIAN scale

Allega, O. R., Leng, X., Vaccarino, A., Skelly, M., Lanzini, M., Hidalgo, M. P., Soares, C.N., Kennedy, S.H., Frey, B. N. (2017). Performance of the biological rhythms interview for assessment in neuropsychiatry: An item response theory and actigraphy analysis. Journal of Affective Disorders, 225, 54-63. doi:10.1016/j.jad.2017.07.047
(Abstract  here)

Review on Oral Ketamine

Al Shirawi, M., Kennedy, S., Ho, K., Byrne, R., & Downar, J. (2017). Oral Ketamine in Treatment-Resistant Depression. Journal of Clinical Psychopharmacology, 37(4), 464-467. doi:10.1097/JCP.0000000000000717.
(Abstract  here)

Publication on the Depression Inventory Development (DID)

Vaccarino, A., Evans, K., Kalali, A., Kennedy, S., Engelhardt, N., Frey, B., Greist, J.H., Koback, K.A., Lam, R.W., MacQueen, G., Milev, R., Placenza, F.M., Ravindran, A.V., Sheehan, D.V., Sills, T.,  Williams, J.B.W. (2016). The Depression Inventory Development Workgroup: A Collaborative, Empirically Driven Initiative to Develop a New Assessment Tool for Major Depressive Disorder. Innovations in Clinical Neuroscience, 1(13), 9-10, 20-31.
(Abstract  here)

Publication on the CAN-BIND-1 Protocol

Lam, R. W., Milev, R., Rotzinger, S., Andreazza, A. C., Blier, P., Brenner, C., Daskalakis, Z.J., Dharsee, M., Downar, J., Evans, K.R., Farzan, F., Foster, J.A., Frey, B.N., Geraci, J., Giacobbe, P., Feilotter, H.E., Hall, G.B., Harkness, K.L., Hassel, S., Ismail, Z., Leri, F., Liotti, M., MacQueen, G.M., McAndrews, M., Minuzzi, L., Müller, D.M., Parikh, S.V., Placenza, F.M., Quilty, L.C., Ravindran. A.V., Salomons, T.V., Soares, C.N., Strother, S.C., Turecki, G., Vaccarino, A.L., Vila-Rodriguez, F., Kennedy, S.H. (2016). Discovering biomarkers for antidepressant response: protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort. BMC Psychiatry, 16(1). doi:10.1186/s12888-016-0785-x
(Abstract  here)

Publication describing the CAN-BIND research vision

Kennedy, S. H., Downar, J., Evans, K. R., Feilotter, H., Lam, R. W., Macqueen, G. M., Milev, R., Parikh, S.V., Rotzinger, S. Soares, C. (2012). The Canadian Biomarker Integration Network in Depression (CAN-BIND): Advances in Response Prediction. Current Pharmaceutical Design, 18(36), 5976-5989. doi:10.2174/138161212803523635
(Abstract  here)