CAN-BIND Studies

Please Select A Study That Interests You From The Drop Down Menu Below:

1) CAN-BIND-1: Antidepressant Medication Study

Full study name: CAN-BIND (Canadian Biomarker Integrated Network in Depression)
Study lead: Dr. Sidney Kennedy

Description 
Depression is usually treated with oral antidepressant medication, but it is difficult to know before treatment begins whether or not a medication will work for a particular individual. Many patients try multiple antidepressant medications before finding the ‘right one’. The goal of this study is to identify important factors that can accurately predict an individual’s treatment response to antidepressant medication. This research may help doctors to match patients with the right medication quickly and effectively.

What do participants do in this study?
In this study, participants are treated by a psychiatrist with a standard antidepressant for 16 weeks. During the study, participants complete questionnaires that assess mood, personality, cognitive and lifestyle factors. In addition, participants provide blood and urine samples, which are evaluated to identify genes and proteins that may predict treatment response. These biological features or markers are known as biomarkers. Participants also have their brains imaged using magnetic resonance imaging (MRI) and their brain function assessed using electroencephalography (EEG). All of this information will be evaluated by our researchers in the hopes of finding biomarkers that predict treatment response in patients with depression.

Where is the study taking place?
This study is recruiting patients in Toronto, Hamilton, Kingston, Vancouver and Calgary

Where can I find more information?
See Flyer For More Details And To Find Out How To Join


2) CAN-BIND-2: Brain Stimulation Study

Full study name: The Canadian rTMS Treatment Biomarker Network in Depression (CARTBIND)
Study leads: Dr. Daniel Blumberger, Dr. Jeff Daskalakis, Dr. Jonathan Downar and Dr. Fidel Vila-Rodriguez

Description
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique approved as a treatment for major depression by Health Canada. rTMS involves stimulating specific areas of the brain with magnetic field pulses. This study will focus on a specific type of stimulation called theta-burst stimulation. The goal of the study is to identify biomarkers of response to rTMS treatment.

What do participants do in this study?
In this study, participants will undergo rTMS treatment over six weeks. Before rTMS treatment begins, participants will have their brains imaged using magnetic resonance imaging (MRI) to help aim the stimulator correctly during treatment. There will be two more MRI sessions during the study for research purposes to understand how brain structure and activity relates to treatment response. Participants will also complete health-related questionnaires, provide blood samples and undergo neurophysiology testing using EEG.

Where is the study taking place?
This study will be recruiting patients in Toronto and Vancouver.

Where can I find more information?
For more information on rTMS at the various study sites:


3) CAN-BIND-3: Adolescent Mental Health Study

Description
The goal of this study is to improve the ability to identify youth at risk of serious mental illness (SMI). Changes in mood, thinking or behaviour can be early indicators of mental illness. It is not yet known why these symptoms go away in some people, while in others the symptoms worsen and lead to a serious mental illness. Clinical, social, cognitive, neuroimaging and molecular factors are assessed in this study to identify risk indicators for developing serious mental illness in youth.

What do participants do in this study?
In this study, participants complete health-related questionnaires and cognitive tasks that evaluate concentration, problem-solving and memory. Participants have their brains imaged using magnetic resonance imaging (MRI) to help researchers understand the differences in brain structure and function between youth who do and do not develop serious mental illness. Blood samples are also provided to help researchers understand the biological basis of mental illnesses. This information may be used to develop new tests to diagnose or predict mental illnesses or to identify new treatments for diseases.

Where is the study taking place?
This study is recruiting patients in Calgary and Toronto.

Where can I find more information?
Georgia Carstensen, MIPH
Phone: 403.210.8740
Email: Georgia.carstensen@ucalgary.ca


4) CAN-BIND-4: Stress and Reward Study

Full study name: Stress and Reward Anhedonia
Study lead: Dr. Kate Harkness

Description coming soon


5) CAN-BIND-5: Suicide Markers Study

Full study name: Pain, Reward, Attention and Neurocircuitry: Biomarkers of Suicidality
Study leads: Dr. Sakina Rizvi, Dr. Sidney Kennedy

Description:
This study hopes to identify biological markers (e.g. brain activity, behavioural tests, genetics) to help us determine what can predict suicide attempt, and identify potential new interventions.

What do participants do in this study?
Participants will complete 5 visits over a one year period. At the first visit and at 1 year, participants will complete scales to measure mood and suicidal risk, as well as undergo brain imaging, blood collection, and tests of learning, memory, attention, and pain perception.

Where is the study taking place?
This study will be recruiting in Toronto soon.

Where can I find more information?
Nicole Edgar
Email: EdgarN@smh.ca
Phone: 416-864-6099
Flyer For Healthy Controls
Flyer For Patients With Depression


6) CAN-BIND-6: Cognitive Behavioural Therapy (CBT) Study

Description Coming Soon


7) CAN-BIND-7: Pilot Study: Music Therapy Studies

Full study name: Examining the effect of Music and Rhythmic Sensory Stimulation on Major Depressive Disorder
Study leads: Dr. Sidney Kennedy, Dr. Lee Bartel, Dr. Thenille Braun Janzen

Description: 
The goal of this study is to explore whether music- and sound-based therapies, used in combination with standard treatment, can further relieve symptoms of depression.

What do participants do in this study? 
Participants will complete a 5-week music intervention at home. The relaxing sound and musical tracks used in this program were specially composed to stimulate the brain with gamma frequency sounds (30-70 Hz). Participants are provided with a therapeutic device that has special speakers to deliver the sounds and music used in this study, and will be required use the device 30 minutes daily, for 5 days per week, completing a total of 5 weeks of treatment. Participants will complete mood and health-related questionnaires and have their brain activity measured using electroencephalography (EEG) before and after the 5-week therapy.

Where is the study taking place? 
This study is recruiting participants in Toronto.

Where can I find more information? 
-Thenille Braun Janzen
-Email: Thenille.BraunJanzen@uhn.ca
-Phone: 416-603-5800 ext. 6365
-Fax: 416-603-5368
-Referral Form: ReferralFormMusic.pdf