Research

Publications


Recent publications

GWAS-based Machine Learning Approach to Predict Duloxetine Response in Major Depressive Disorder  
Maciukiewicz, M., V.S. Marshe, A.C. Hauschild, J.A. Foster, S. Rotzinger, J.L. Kennedy, S.H. Kennedy, D.J. Mueller, and J. Geraci. (2018). GWAS-based machine learning approach to predict duloxetine response in major depressive disorder. J Psychiatr Res 99:62-68.

Commentary: More Data, More Answers: Picking the Optimal Antidepressant
Parikh, S.V., Kennedy, S.H. (2018). More Data, More Answers: Picking the Optimal Antidepressant. The Lancet. DOI: 10.1097/YCT.0000000000000486.

Presentation and Neurobiology of Anhedonia in Mood Disorders: Commonalities and Distinctions
Rizvi S.J., Lambert C., Kennedy S. Presentation and Neurobiology of Anhedonia in Mood Disorders: Commonalities and Distinctions. Curr Psychiatry Rep. 20(2):13. doi: 10.1007/s11920-018-0877-z.

Improvements in Health-Related Quality of Life with Electroconvulsive Therapy: A Meta-Analysis
Giacobbe, P., Rakita, U., Penner-Geoke, K., Feffer, K., Flint, A.J., Kennedy, S.H., Downar, J. (2018). Improvements in Health-Related Quality of Life with Electroconvulsive Therapy: A Meta-Analysis. The Journal of ECT. DOI: 10.1097/YCT.0000000000000486.

Fatigue in Patients with Major Depressive Disorder: Prevalence, Burden and Pharmacological Approaches to Management
Ghanean, H., Ceniti, A.K., Kennedy S.H. (2018). Fatigue in Patients with Major Depressive Disorder: Prevalence, Burden and Pharmacological Approaches to Management. CNS Drugs. DOI: 10.1007/s40263-018-0490-z.

2017

Unpacking Major Depressive Disorder: From Classification to Treatment Selection
Kennedy, S.H., Ceniti, A. K. (2017). Unpacking Major Depressive Disorder: From classification to treatment selection. The Canadian Journal of Psychiatry, 1-6. doi.org/10.1177/0706743717748883

Effect of steady-state methadone on high fructose corn syrup consumption in rats
Daniels, S., Pratt, M., Zhou, Y., Leri, F. (2017). Effect of steady-state methadone on high fructose corn syrup consumption in rats. Journal of Psychopharmacology. doi: 10.1177/0269881117742116.

Major depression and its treatment: microRNAs as peripheral biomarkers of diagnosis and treatment response
Lopez, J. P., Kos, A., & Turecki, G. (2017). Major depression and its treatment: microRNAs as peripheral biomarkers of diagnosis and treatment response. Current Opinion in Psychiatry, 1. doi:10.1097/yco.0000000000000379

Smart phone technologies and ecological momentary data: is this the way forward on depression management and research?
Frank, E., Pong, J., Asher, Y., & Soares, C. N. (2017). Smart phone technologies and ecological momentary data. Current Opinion in Psychiatry, 1. doi:10.1097/yco.0000000000000382

The Comparative Effectiveness of Electroencephalographic Indices in Predicting Response to Escitalopram Therapy in Depression: A Pilot Study
Baskaran, A., Farzan, F., Milev, R., Brenner, C. A., Alturi, S., McAndrews, M. P., Blier, P., Evans, K., Foster, J.A., Frey, B.N., Giacobbe, P., Lam, R.W., Leri, F., MacQueen, G.M.,  Müller, D.J., Parikh, S.V., Rotzinger, S., Soares, C.N., Strother, S.C., Turecki, G. Kennedy, S. H. (2017). The comparative effectiveness of electroencephalographic indices in predicting response to escitalopram therapy in depression: A pilot study. Journal of Affective Disorders, 227, 542-549. doi:10.1016/j.jad.2017.10.028

Neuroimaging biomarkers as predictors of treatment outcome in Major Depressive Disorder
Fonseka, T. M., Macqueen, G. M., & Kennedy, S. H. (2017). Neuroimaging biomarkers as predictors of treatment outcome in Major Depressive Disorder. Journal of Affective Disorders. doi:10.1016/j.jad.2017.10.049

The combination of escitalopram and aripiprazole: investigation of psychomotor effects in rats
Hudson, R., Zhou, Y., & Leri, F. (2017). The combination of escitalopram and aripiprazole: Investigation of psychomotor effects in rats. Journal of Psychopharmacology, 31(12), 1605-1614. doi:10.1177/0269881117732515

Big Five aspects of personality interact to predict depression
Allen, T. A., Carey, B. E., Mcbride, C., Bagby, R. M., Deyoung, C. G., & Quilty, L. C. (2017). Big Five aspects of personality interact to predict depression. Journal of Personality. doi:10.1111/jopy.12352

Targeting the Microbiome for Mental Health: Hype or Hope?
Foster, J. A. (2017). Targeting the Microbiome for Mental Health: Hype or Hope? Biological Psychiatry, 82(7), 456-457. doi:10.1016/j.biopsych.2017.08.002

Transcriptomic and epigenomic biomarkers of antidepressant response
Belzeaux, R., Lin, R., Ju, C., Chay, M., Fiori, L. M., Lutz, P., & Turecki, G. (2017). Transcriptomic and epigenomic biomarkers of antidepressant response. Journal of Affective Disorders. doi:10.1016/j.jad.2017.08.087

Standardization of Electroencephalography across Multi-site and Multi-investigator Studies: Insight from the Canadian Biomarker Integration Network in Depression
Farzan, F., Atluri, S., Frehlich, M., Dhami, P., Kleffner, K., Price, R., Lam, R.W., Frey, B.N., Milev, R., Ravindran, A., McAndrews, M.P., Wong, W., Blumberger, D., Daskalakis, Z.J., Vila-Rodriguez, F., Alonso, E., Brenner, C.A., Liotti, M., Dharsee, M., Arnott, S.R., Evans, K.R., Rotzinger, S., Kennedy, S. H. (2017). Standardization of electroencephalography for multi-site, multi-platform and multi-investigator studies: insights from the Canadian Biomarker Integration Network in Depression. Scientific Reports, 7(1). doi:10.1038/s41598-017-07613-x

Oral Ketamine in Treatment-Resistant Depression
Al Shirawi, M., Kennedy, S., Ho, K., Byrne, R., & Downar, J. (2017). Oral Ketamine in Treatment-Resistant Depression. Journal of Clinical Psychopharmacology, 37(4), 464-467. doi:10.1097/JCP.0000000000000717.

Investigation of miR-1202, miR-135a, and miR-16 in Major Depressive Disorder and Antidepressant Response
Fiori, L. M., Lopez, J. P., Richard-Devantoy, S., Berlim, M., Chachamovich, E., Jollant, F., Foster J., Rotzinger  S., Kennedy S.H., Turecki, G. (2017). Investigation of miR-1202, miR-135a, and miR-16 in Major Depressive Disorder and Antidepressant Response. International Journal of Neuropsychopharmacology, 20(8), 619-623. doi:10.1093/ijnp/pyx034

Performance of the Biological Rhythms Interview for Assessment in Neuropsychiatry: An Item Response Theory and Actigraphy Analysis
Allega, O. R., Leng, X., Vaccarino, A., Skelly, M., Lanzini, M., Hidalgo, M. P., Soares, C.N., Kennedy, S.H., Frey, B. N. (2017). Performance of the biological rhythms interview for assessment in neuropsychiatry: An item response theory and actigraphy analysis. Journal of Affective Disorders, 225, 54-63. doi:10.1016/j.jad.2017.07.047

Oral Ketamine in Treatment-Resistant Depression
Al Shirawi, M. I., Kennedy, S. H., Ho, K.T., Byrne, R., Downar, J. (2017). Oral Ketamine in Treatment-Resistant Depression. Journal of Clinical Psychopharmacology, 37(4), 464-467. doi: 10.1097/JCP.0000000000000717

Genome-wide association studies of placebo and duloxetine response in major depressive disorder
Maciukiewicz, M., Marshe, V. S., Tiwari, A. K., Fonseka, T. M., Freeman, N., Kennedy, J. L., Rotzinger S, Foster J.A., Kennedy S.H., Müller, D.J. (2017). Genome-wide association studies of placebo and duloxetine response in major depressive disorder. The Pharmacogenomics Journal. doi:10.1038/tpj.2017.29

Neuroimaging tests for clinical psychiatry: Are we there yet?
Leyton, M., & Kennedy, S. H. (2017). Neuroimaging tests for clinical psychiatry: Are we there yet? Journal of Psychiatry and Neuroscience, 42(4), 219-221. doi:10.1503/jpn.170109

MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes
Lopez, J. P., Fiori, L. M., Cruceanu, C., Lin, R., Labonte, B., Cates, H. M., Heller, E.A., Vialou, V., Ku, S.M., Gerald, C., Han, M.H., Foster, J., Frey, B.N., Soares, C.N., Mueller, D.J., Farzan, F., Leri, F., MacQueen, G.M., Feilotter, H., Tyryshkin, K., Evans, K.R., Giacobbe, P., Blier, P., Lam, R.W., Milev, R., Parihk, S.V., Rotzinger, S., Strother, S.C., Lewis, C.M., Aitchison, K. J., Wittenberg, G.M., Mechawar, N., Nestler, E.J., Uher, R., Kennedy, S.H., Turecki, G. (2017). MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes. Nature Communications, 8, 15497. doi:10.1038/ncomms15497

The Relationship between Fatty Acids and Different Depression-Related Brain Regions, and Their Potential Role as Biomarkers of Response to Antidepressants
Fernandes, M., Mutch, D., & Leri, F. (2017). The Relationship between Fatty Acids and Different Depression-Related Brain Regions, and Their Potential Role as Biomarkers of Response to Antidepressants. Nutrients, 9(3), 298. doi:10.3390/nu9030298

Is tetraethyl lead poison affecting contemporary indigenous suicides in Ontario, Canada?
Fonseka, T. M., Macqueen, G. M., & Kennedy, S. H. (2017). Neuroimaging biomarkers as predictors of treatment outcome in Major Depressive Disorder. Journal of Affective Disorders. doi:10.1016/j.jad.2017.10.049

Neuroimaging biomarkers as predictors of treatment outcome in Major Depressive Disorder
Fonseka, T.M., MacQueen, G.M., Kennedy, S.H. (2017). Neuroimaging Biomarkers as Predictors of Treatment Outcome in Major Depressive Disorder. Journal of Affective Disorders. doi: 10.1016/j.jad.2017.10.049

 

2016

The Depression Inventory Development Workgroup: A Collaborative, Empirically Driven Initiative to Develop a New Assessment Tool for Major Depressive Disorder
Vaccarino, A., Evans, K., Kalali, A., Kennedy, S., Engelhardt, N., Frey, B., Greist, J.H., Koback, K.A., Lam, R.W., MacQueen, G., Milev, R., Placenza, F.M., Ravindran, A.V., Sheehan, D.V., Sills, T.,  Williams, J.B.W. (2016). The Depression Inventory Development Workgroup: A Collaborative, Empirically Driven Initiative to Develop a New Assessment Tool for Major Depressive Disorder. Innovations in Clinical Neuroscience, 1(13), 9-10, 20-31.

Discovering biomarkers for antidepressant response: protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort
Lam, R. W., Milev, R., Rotzinger, S., Andreazza, A. C., Blier, P., Brenner, C., Daskalakis, Z.J., Dharsee, M., Downar, J., Evans, K.R., Farzan, F., Foster, J.A., Frey, B.N., Geraci, J., Giacobbe, P., Feilotter, H.E., Hall, G.B., Harkness, K.L., Hassel, S., Ismail, Z., Leri, F., Liotti, M., MacQueen, G.M., McAndrews, M., Minuzzi, L., Müller, D.M., Parikh, S.V., Placenza, F.M., Quilty, L.C., Ravindran. A.V., Salomons, T.V., Soares, C.N., Strother, S.C., Turecki, G., Vaccarino, A.L., Vila-Rodriguez, F., Kennedy, S.H. (2016). Discovering biomarkers for antidepressant response: protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort. BMC Psychiatry, 16(1). doi:10.1186/s12888-016-0785-x

Altered monoamine system activities after prenatal and adult stress: A role for stress resilience?
Oosterhof, C. A., Mansari, M. E., Merali, Z., & Blier, P. (2016). Altered monoamine system activities after prenatal and adult stress: A role for stress resilience? Brain Research, 1642, 409-418. doi:10.1016/j.brainres.2016.04.032

Alterations of naltrexone-induced conditioned place avoidance by pre-exposure to high fructose corn syrup or heroin in Sprague-Dawley rats
Daniels, S., Marshall, P., & Leri, F. (2015). Alterations of naltrexone-induced conditioned place avoidance by pre-exposure to high fructose corn syrup or heroin in Sprague–Dawley rats. Psychopharmacology, 233(3), 425-433. doi:10.1007/s00213-015-4121-9

2015

Genetic variation in IL-1β, IL-2, IL-6, TSPO and BDNF and response to duloxetine or placebo treatment in major depressive disorder
Maciukiewicz M, et al. (2015). Genetic variation in IL-1beta, IL-2, IL-6, TSPO and BDNF and response to duloxetine or placebo treatment in major depressive disorder. Pharmacogenomics, 16(17):1919-1929. 

Zebrafish models of major depressive disorders
Fonseka, T. M., Wen, X., Foster, J. A., & Kennedy, S.H. (2015). Zebrafish models of major depressive disorders. Journal of Neuroscience Research, 94(1), 3-14. doi:10.1002/jnr.23639

Fructose: Glucose Ratios—A Study of Sugar Self-Administration and Associated Neural and Physiological Responses in the Rat
Levy, A., Marshall, P., Zhou, Y., Kreek, M., Kent, K., Daniels, S., Shore, A., Downs, T., Fernandes, M.F., Mutch, D.M., Leri, F. (2015). Fructose:Glucose Ratios—A Study of Sugar Self-Administration and Associated Neural and Physiological Responses in the Rat. Nutrients, 7(5), 3869-3890. doi:10.3390/nu7053869

2014 and prior

Restoration of serotonin neuronal firing following long-term administration of bupropion but not paroxetine in olfactory bulbectomized rats
El Mansari, M., Manta, S., Oosterhof, C., Iskandrani, K. S., Chenu, F., Shim, S., & Blier, P. (2014). Restoration of Serotonin Neuronal Firing Following Long-Term Administration of Bupropion but Not Paroxetine in Olfactory Bulbectomized Rats. International Journal of Neuropsychopharmacology, 18(4). doi:10.1093/ijnp/pyu050

A Novel Procedure for Evaluating the Reinforcing Properties of Tastants in Laboratory Rats: Operant Intraoral Self-administration
Levy, A., Limebeer, C. L., Ferdinand, J., Shillingford, U., Parker, L. A., & Leri, F. (2014). A Novel Procedure for Evaluating the Reinforcing Properties of Tastants in Laboratory Rats: Operant Intraoral Self-administration. Journal of Visualized Experiments, (84). doi:10.3791/50956

The Canadian Biomarker Integration Network in Depression (CAN-BIND): advances in response prediction
Kennedy, S. H., Downar, J., Evans, K. R., Feilotter, H., Lam, R. W., Macqueen, G. M., Milev, R., Parikh, S.V., Rotzinger, S. Soares, C. (2012). The Canadian Biomarker Integration Network in Depression (CAN-BIND): Advances in Response Prediction. Current Pharmaceutical Design, 18(36), 5976-5989. doi:10.2174/138161212803523635