Publications

Publications


2024
Ayyash, S., Davis, A. D., Alders, G. L., MacQueen, G., Strother, S. C., Hassel, S., Zamyadi, M., Arnott, S. R., Harris, J. K., Lam, R. W., Milev, R., Müller, D. J., Kennedy, S. H., Rotzinger, S., Frey, B. N., Minuzzi, L., & Hall, G. B. (2024). Assessing remission in major depressive disorder using a functional-structural data fusion pipeline: A CAN-BIND-1 study. IBRO Neuroscience Reports, 16, 135–146. https://doi.org/10.1016/j.ibneur.2023.12.011
 
Fu, C. H. Y., Antoniades, M., Erus, G., Garcia, J. A., Fan, Y., Arnone, D., Arnott, S. R., Chen, T., Choi, K. S., Fatt, C. C., Frey, B. N., Frokjaer, V. G., Ganz, M., Godlewska, B. R., Hassel, S., Ho, K., McIntosh, A. M., Qin, K., Rotzinger, S., … Davatzikos, C. (2024). Neuroanatomical dimensions in medication-free individuals with major depressive disorder and treatment response to SSRI antidepressant medications or placebo. Nature Mental Health, 2(2), 164–176. https://doi.org/10.1038/s44220-023-00187-w
 
Ho, N. C. W., Bethlehem, R. A. I., Seidlitz, J., Nogovitsyn, N., Metzak, P., Ballester, P. L., Hassel, S., Rotzinger, S., Poppenk, J., Lam, R. W., Taylor, V. H., Milev, R., Adamson, C., Adler, S., Alexander-Bloch, A. F., Anagnostou, E., Anderson, K. M., Areces-Gonzalez, A., Astle, D. E., … Dunlop, K. (2024). Atypical brain aging and its association with working memory performance in major depressive disorder. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 9(8), 786–799. https://doi.org/10.1016/j.bpsc.2024.04.008
 
Islam, F., Lisoway, A., Oh, E. S., Fiori, L. M., Magarbeh, L., Elsheikh, S. S. M., Kim, H. K., Kloiber, S., Kennedy, J. L., Frey, B. N., Milev, R., Soares, C. N., Parikh, S. V., Placenza, F., Hassel, S., Taylor, V. H., Leri, F., Blier, P., Uher, R., … Müller, D. J. (2024). Integrative genetic variation, dna methylation, and gene expression analysis of escitalopram and aripiprazole treatment outcomes in depression: A CAN-BIND-1 study. Pharmacopsychiatry, 57(05), 232–244. https://doi.org/10.1055/a-2313-9979
 
Islam, F., Magarbeh, L., Elsheikh, S. S. M., Kloiber, S., Espinola, C. W., Bhat, V., Frey, B. N., Milev, R., Soares, C. N., Parikh, S. V., Placenza, F., Hassel, S., Taylor, V. H., Leri, F., Blier, P., Uher, R., Farzan, F., Lam, R. W., Turecki, G., … Müller, D. J. (2024). Influence of cyp2c19 , cyp2d6 , and abcb1 gene variants and serum levels of escitalopram and aripiprazole on treatment-emergent sexual dysfunction: A Canadian Biomarker Integration Network in Depression-1 (CAN-BIND-1) study. The Canadian Journal of Psychiatry, 69(3), 183–195. https://doi.org/10.1177/07067437231203433
 
Mazurka, R., Cunningham, S., Hassel, S., Foster, J. A., Nogovitsyn, N., Fiori, L. M., Strother, S. C., Arnott, S. R., Frey, B. N., Lam, R. W., MacQueen, G. M., Milev, R. V., Rotzinger, S., Turecki, G., Kennedy, S. H., & Harkness, K. L. (2024). Relation of hippocampal volume and SGK1 gene expression to treatment remission in major depression is moderated by childhood maltreatment: A CAN-BIND-1 report. European Neuropsychopharmacology, 78, 71–80. https://doi.org/10.1016/j.euroneuro.2023.12.003
 
Min, S., Mazurka, R., Pizzagalli, D. A., Whitton, A. E., Milev, R. V., Bagby, R. M., Kennedy, S. H., & Harkness, K. L. (2024). Stressful life events and reward processing in adults: Moderation by depression and anhedonia. Depression and Anxiety, 2024, 1–13. https://doi.org/10.1155/2024/8853631
 
Nogovitsyn, N., Ballester, P., Lasby, M., Dunlop, K., Ceniti, A. K., Squires, S., Rowe, J., Ho, K., Suh, J., Hassel, S., Souza, R., Casseb, R. F., Harris, J. K., Zamyadi, M., Arnott, S. R., Strother, S. C., Hall, G., Lam, R. W., Poppenk, J., … Frey, B. N. (2024). An empirical analysis of structural neuroimaging profiles in a staging model of depression. Journal of Affective Disorders, 351, 631–640. https://doi.org/10.1016/j.jad.2024.01.246
 
Nunes, A., Pavlova, B., Cunningham, J. E. A., Nuñez, J.-J., Quilty, L. C., Foster, J. A., Harkness, K. L., Ho, K., Lam, R. W., Li, Q. S., Milev, R., Rotzinger, S., Soares, C. N., Taylor, V. H., Turecki, G., Kennedy, S. H., Frey, B. N., Rudzicz, F., & Uher, R. (2024). Depression-Anxiety Coupling Strength as a predictor of relapse in major depressive disorder: A CAN-BIND wellness monitoring study report. Journal of Affective Disorders, 361, 189–197. https://doi.org/10.1016/j.jad.2024.06.023
 
Vaccarino, S. R., Wang, S., Rizvi, S. J., Lou, W., Hassel, S., MacQueen, G. M., Ho, K., Frey, B. N., Lam, R. W., Milev, R. V., Rotzinger, S., Ravindran, A. V., Strother, S. C., & Kennedy, S. H. (2024). Functional neuroimaging biomarkers of anhedonia response to escitalopram plus adjunct aripiprazole treatment for major depressive disorder. BJPsych Open, 10(1), e18. https://doi.org/10.1192/bjo.2023.588
 
Van Der Wijk, G., Zamyadi, M., Bray, S., Hassel, S., Arnott, S. R., Frey, B. N., Kennedy, S. H., Davis, A. D., Hall, G. B., Lam, R. W., Milev, R., Müller, D. J., Parikh, S., Soares, C., Macqueen, G. M., Strother, S. C., & Protzner, A. B. (2024). Large individual differences in functional connectivity in the context of major depression and antidepressant pharmacotherapy. Eneuro, 11(6), ENEURO.0286-23.2024. https://doi.org/10.1523/ENEURO.0286-23.2024
2023

Ballester, P. L., Suh, J. S., Ho, N. C. W., Liang, L., Hassel, S., Strother, S. C., Arnott, S. R., Minuzzi, L., Sassi, R. B., Lam, R. W., Milev, R., Müller, D. J., Taylor, V. H., Kennedy, S. H., Reilly, J. P., Palaniyappan, L., Dunlop, K., & Frey, B. N. (2023). Gray matter volume drives the brain age gap in schizophrenia: A SHAP study. Schizophrenia, 9(1), 3. https://doi.org/10.1038/s41537-022-00330-z

Dama, M., Wu, M., Tassone, V. K., Demchenko, I., Frey, B. N., Milev, R. V., Ravindran, A. V., Parikh, S. V., Rotzinger, S., Lou, W., Lam, R. W., Kennedy, S. H., & Bhat, V. (2023). The course of insomnia symptoms during the acute treatment of major depressive disorder: A CAN-BIND-1 report. Psychiatry Research, 325, 115222. https://doi.org/10.1016/j.psychres.2023.115222

Fu, C. H. Y., Erus, G., Fan, Y., Antoniades, M., Arnone, D., Arnott, S. R., Chen, T., Choi, K. S., Fatt, C. C., Frey, B. N., Frokjaer, V. G., Ganz, M., Garcia, J., Godlewska, B. R., Hassel, S., Ho, K., McIntosh, A. M., Qin, K., Rotzinger, S., … Davatzikos, C. (2023). AI-based dimensional neuroimaging system for characterizing heterogeneity in brain structure and function in major depressive disorder: COORDINATE-MDD consortium design and rationale. BMC Psychiatry, 23(1), 59. https://doi.org/10.1186/s12888-022-04509-7

Harkness, K. L., Chakrabarty, T., Rizvi, S. J., Mazurka, R., Quilty, L., Uher, R., Milev, R. V., Frey, B. N., Parikh, S. V., Foster, J. A., Rotzinger, S., Kennedy, S. H., & Lam, R. W. (2023). The differential relation of emotional, physical, and sexual abuse histories to antidepressant treatment remission and persistence of anhedonia in major depression: A can-bind-1 report. The Canadian Journal of Psychiatry, 68(8), 586–595. https://doi.org/10.1177/07067437231156255

Islam, F., Marshe, V. S., Magarbeh, L., Frey, B. N., Milev, R. V., Soares, C. N., Parikh, S. V., Placenza, F., Strother, S. C., Hassel, S., Taylor, V. H., Leri, F., Blier, P., Uher, R., Farzan, F., Lam, R. W., Turecki, G., Foster, J. A., Rotzinger, S., … Müller, D. J. (2022). Effects of CYP2C19 and CYP2D6 gene variants on escitalopram and aripiprazole treatment outcome and serum levels: Results from the CAN-BIND 1 study. Translational Psychiatry, 12(1), 366. https://doi.org/10.1038/s41398-022-02124-4

Magarbeh, L., Hassel, C., Choi, M., Islam, F., Marshe, V. S., Zai, C. C., Zuberi, R., Gammal, R. S., Men, X., Scherf‐Clavel, M., Enko, D., Frey, B. N., Milev, R., Soares, C. N., Parikh, S. V., Placenza, F., Strother, S. C., Hassel, S., Taylor, V. H., … Müller, D. J. (2023). abcb1 gene variants and antidepressant treatment outcomes: A systematic review and meta‐analysis including results from the CAN-BIND 1 study. Clinical Pharmacology & Therapeutics, 114(1), 88–117. https://doi.org/10.1002/cpt.2854

Melanson, B., Wolter, M., Leatham, Z., Lapointe, T., Kennedy, S., & Leri, F. (2023). Conditioned anti-immobility by ketamine: A comparison to escitalopram and bupropion. Experimental and Clinical Psychopharmacology, 31(2), 350–361. https://doi.org/10.1037/pha0000573

Rnic, K. et al. Predicting recurrence of major depressive episodes using the Depression Implicit Association Test: A Canadian biomarker integration network in depression (CAN-BIND) reportPsychiatry Research 330, 115606 (2023).

Sajjadian, M., Lam, R. W., Milev, R., Rotzinger, S., Frey, B. N., Soares, C. N., Parikh, S. V., Foster, J. A., Turecki, G., Müller, D. J., Strother, S. C., Farzan, F., Kennedy, S. H., & Uher, R. (2021). Machine learning in the prediction of depression treatment outcomes: A systematic review and meta-analysis. Psychological Medicine, 51(16), 2742–2751. https://doi.org/10.1017/S0033291721003871

Dikaios, K., Rempel, S., Dumpala, S. H., Oore, S., Kiefte, M., & Uher, R. (2023). Applications of speech analysis in psychiatry. Harvard Review of Psychiatry, 31(1), 1–13. https://doi.org/10.1097/HRP.0000000000000356

2022

Sajjadian, M., Uher, R., Ho, K., Hassel, S., Milev, R., Frey, B. N., Farzan, F., Blier, P., Foster, J. A., Parikh, S. V., Müller, D. J., Rotzinger, S., Soares, C. N., Turecki, G., Taylor, V. H., Lam, R. W., Strother, S. C., & Kennedy, S. H. (2022). Prediction of depression treatment outcome from multimodal data: a CAN-BIND-1 report.  Psychological medicine, 1–11. Advance online publication. https://doi.org/10.1017/S0033291722002124

Ceniti, A. K., Abdelmoemin, W. R., Ho, K., Kang, Y., Placenza, F., Laframboise, R., … & Kennedy, S. H. (2022). “One Degree of Separation”: A Mixed-Methods Evaluation of Canadian Mental Health Care User and Provider Experiences With Remote Care During COVID-19. The Canadian Journal of Psychiatry, 07067437211070656.

Dhami, P., Quilty, L. C., Schwartzmann, B., Uher, R., Allen, T. A., Kloiber, S., … & Farzan, F. (2022). Response Inhibition and Predicting Response to Pharmacological and Cognitive Behavioral Therapy Treatments for Major Depressive Disorder: A CAN-BIND Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.

Espinola, C. W., Khoo, Y., Parmar, R., Demchenko, I., Frey, B. N., Milev, R. V., … & CAN‐BIND Investigator Team. (2022). Pretreatment anxious depression as a predictor of side effect frequency and severity in escitalopram and aripiprazole adjunctive therapy. Brain and Behavior, e2555.

Nogovitsyn, N., Metzak, P. D., Casseb, R. F., Souza, R., Harris, J. K., Prati, L. M., … & Addington, J. (2022). Cerebello-limbic functional connectivity patterns in youth at clinical high risk for psychosis. Schizophrenia Research240, 220-227.

Vaccarino, A. L., Beaton, D., Black, S. E., Blier, P., Farzan, F., Finger, E., … & Evans, K. R. (2022). Common Data Elements to Facilitate Sharing and Re-use of Participant-Level Data: Assessment of Psychiatric Comorbidity Across Brain Disorders. Frontiers in psychiatry, 65.

Espinola, C. W., Khoo, Y., Parmar, R., Demchenko, I., Frey, B. N., Milev, R. V., Ravindran, A. V., Parikh, S. V., Ho, K., Rotzinger, S., Lou, W., Lam, R. W., Kennedy, S. H., & Bhat, V. (2022). Males and females differ in reported sexual functioning with escitalopram treatment for major depressive disorder: A CAN-BIND-1 study report.  Journal of psychopharmacology (Oxford, England), 36(5), 604–613. https://doi.org/10.1177/02698811221095832

Khoo, Y., Demchenko, I., Frey, B. N., Milev, R. V., Ravindran, A. V., Parikh, S. V., Ho, K., Rotzinger, S., Lou, W., Lam, R. W., Kennedy, S. H., Bhat, V., & CAN-BIND Investigator Team (2022). Baseline anxiety, and early anxiety/depression improvement in anxious depression predicts treatment outcomes with escitalopram: A CAN-BIND-1 study report.  Journal of affective disorders, 300, 50–58. https://doi.org/10.1016/j.jad.2021.12.027

Dama, M., Khoo, Y., Frey, B. N., Milev, R. V., Ravindran, A. V., Parikh, S. V., … & Team, C. B. I. (2022). Rhythmicity of sleep and clinical outcomes in major depressive disorder: A CAN-BIND-1 Report.  Journal of Affective Disorders Reports, 100370.

Harris, J. K., Hassel, S., Davis, A. D., Zamyadi, M., Arnott, S. R., Milev, R., Lam, R. W., Frey, B. N., Hall, G. B., Müller, D. J., Rotzinger, S., Kennedy, S. H., Strother, S. C., MacQueen, G. M., & Greiner, R. (2022). Predicting escitalopram treatment response from pre-treatment and early response resting state fMRI in a multi-site sample: A CAN-BIND-1 report.  NeuroImage. Clinical, 35, 103120. https://doi.org/10.1016/j.nicl.2022.103120

Hicks, O., McInerney, S. J., Lam, R. W., Milev, R. V., Frey, B. N., Soares, C. N., Foster, J. A., Rotzinger, S., Kennedy, S. H., & Harkness, K. L. (2022). Acute and chronic stress predict anti-depressant treatment outcome and naturalistic course of major depression: A CAN-BIND report.  Journal of affective disorders, 313, 8–14. https://doi.org/10.1016/j.jad.2022.06.058

2021

Allen, T. A., Harkness, K. L., Lam, R. W., Milev, R., Frey, B. N., Mueller, D. J., … & Quilty, L. C. (2021). Interactions between neuroticism and stressful life events predict response to pharmacotherapy for major depression: A CAN‐BIND 1 report. Personality and Mental Health15(4), 273-282.

Anteraper, S. A., Guell, X., Lee, Y. J., Raya, J., Demchenko, I., Churchill, N. W., … & Bhat, V. (2022). Cerebello-cerebral Functional Connectivity Networks in Major Depressive Disorder: A CAN-BIND-1 Study Report. The Cerebellum, 1-11.

Ayyash, S., Davis, A. D., Alders, G. L., MacQueen, G., Strother, S. C., Hassel, S., … & CAN‐BIND Investigator Team. (2021). Exploring brain connectivity changes in major depressive disorder using functional‐structural data fusion: A CAN‐BIND‐1 study. Human brain mapping.

Ballester, P. L., Romano, M. T., de Azevedo Cardoso, T., Hassel, S., Strother, S. C., Kennedy, S. H., & Frey, B. N. (2021). Brain age in mood and psychotic disorders: a systematic review and meta‐analysis. Acta Psychiatrica Scandinavica.

Ballester, P. L., Suh, J. S., Nogovitsyn, N., Hassel, S., Strother, S. C., Arnott, S. R., … & Team, C. B. I. (2021). Accelerated brain aging in major depressive disorder and antidepressant treatment response: A CAN-BIND report. NeuroImage: Clinical32, 102864.

Caspani, G., Turecki, G., Lam, R. W., Milev, R. V., Frey, B. N., MacQueen, G. M., … & Swann, J. R. (2021). Metabolomic signatures associated with depression and predictors of antidepressant response in humans: A CAN-BIND-1 report. Communications Biology4(1), 1-11.

Cunningham, S., Mazurka, R., Wynne-Edwards, K. E., Milev, R. V., Pizzagalli, D. A., Kennedy, S., & Harkness, K. L. (2021). Cortisol reactivity to stress predicts behavioral responsivity to reward moderation by sex, depression, and anhedonia. Journal of Affective Disorders293, 1-8.

Davis, A. D., Hassel, S., Arnott, S. R., Hall, G. B., Harris, J. K., Zamyadi, M., … & Strother, S. C. (2022). Biophysical compartment models for single-shell diffusion MRI in the human brain: a model fitting comparison. Physics in Medicine & Biology67(5), 055009.

Kayvanrad, A., Arnott, S. R., Churchill, N., Hassel, S., Chemparathy, A., Dong, F., … & Strother, S. (2021). Resting state fMRI scanner instabilities revealed by longitudinal phantom scans in a multi-center study. NeuroImage237, 118197.

Liang, S., Beaton, D., Arnott, S. R., Gee, T., Zamyadi, M., Bartha, R., … & ONDRI Investigators. (2021). Magnetic Resonance Imaging Sequence Identification Using a Metadata Learning Approach. Frontiers in Neuroinformatics15.

Morton, E., Bhat, V., Giacobbe, P., Lou, W., Michalak, E. E., Chakrabarty, T., … & Lam, R. W. (2021). Impacts on quality of life with escitalopram monotherapy and aripiprazole augmentation in patients with major depressive disorder: a CAN-BIND report. Pharmacopsychiatry.

Morton, E., Bhat, V., Giacobbe, P., Lou, W., Michalak, E. E., McInerney, S., … & Lam, R. W. (2021). Predictors of Quality of Life Improvement with Escitalopram and Adjunctive Aripiprazole in Patients with Major Depressive Disorder: A CAN-BIND Study Report. CNS drugs35(4), 439-450.

Nunez, J. J., Nguyen, T. T., Zhou, Y., Cao, B., Ng, R. T., Chen, J., … & Lam, R. W. (2021). Replication of machine learning methods to predict treatment outcome with antidepressant medications in patients with major depressive disorder from STAR* D and CAN-BIND-1. PloS one16(6), e0253023.

Rnic, K., Jung, Y. E., Torres, I., Chakrabarty, T., LeMoult, J., Vaccarino, A. L., … & Team, C. B. I. (2021). Association between discrepancy in objective and subjective cognitive abilities and treatment response in patients with major depressive disorder: A CAN-BIND-1 study report. Journal of Affective Disorders295, 1095-1101.

Saeedi, S., Nagy, C., Ibrahim, P., Theroux, J. F., Wakid, M., Fiori, L., … & Turecki, G. (2021). Neuron-derived extracellular vesicles extracted from plasma show altered size and miRNA cargo as a function of antidepressant drug response. bioRxiv.

Shakeel, M. K., MacQueen, G., Addington, J., Metzak, P. D., Georgopoulos, G., Bray, S., … & Lebel, C. (2020). White Matter Connectivity in Youth at Risk for Serious Mental Illness: A Longitudinal Analysis. Psychiatry Research: Neuroimaging302, 111106.

Suh, J. S., Fiori, L. M., Ali, M., Harkness, K. L., Ramonas, M., Minuzzi, L., … & Frey, B. N. (2021). Hypothalamus volume and DNA methylation of stress axis genes in major depressive disorder: A CAN-BIND study report. Psychoneuroendocrinology132, 105348.

Theyers, A. E., Zamyadi, M., O’Reilly, M., Bartha, R., Symons, S., MacQueen, G. M., … & Arnott, S. R. (2021). Multisite Comparison of MRI Defacing Software Across Multiple Cohorts. Frontiers in psychiatry12, 189.

van der Wijk, G., Harris, J. K., Hassel, S., Davis, A. D., Zamyadi, M., Arnott, S. R., … & Protzner, A. B. (2021). Baseline functional connectivity in resting state networks associated with depression and remission status after 16 weeks of pharmacotherapy: A CAN-BIND Report. medRxiv.

Yrondi, A., Fiori, L. M., Nogovitsyn, N., Hassel, S., Théroux, J. F., Aouabed, Z., … & Turecki, G. (2021). Association between the expression of lncRNA BASP-AS1 and volume of right hippocampal tail moderated by episode duration in major depressive disorder: a CAN-BIND 1 report. Translational psychiatry11(1), 1-7.

2020

Alders, G. L., Davis, A. D., MacQueen, G., Strother, S. C., Hassel, S., Zamyadi, M., Sharma, G. B., Arnott, S. R., Downar, J., Harris, J. K., Lam, R. W., Milev, R., Müller, D. J., Ravindran, A., Kennedy, S. H., Frey, B. N., Minuzzi, L., & Hall, G. B. (2020). Escitalopram ameliorates differences in neural activity between healthy comparison and major depressive disorder groups on an fMRI emotional conflict task: A CAN-BIND-1 studyJournal of Affective Disorders264, 414-424. https://doi.org/10.1016/j.jad.2019.11.068

Belzeaux, R., Gorgievski, V., Fiori, L. M., Lopez, J. P., Grenier, J., Lin, R., Nagy, C., Ibrahim, E. C., Gascon, E., Courtet, P., Richard-Devantoy, S., Berlim, M., Chachamovich, E., Théroux, J., Dumas, S., Giros, B., Rotzinger, S., Soares, C. N., Foster, J. A., … Turecki, G. (2020). GPR56/ADGRG1 is associated with response to antidepressant treatmentNature Communications11(1). https://doi.org/10.1038/s41467-020-15423-5

Daniels, S., Horman, T., Lapointe, T., Melanson, B., Storace, A., Kennedy, S. H., Frey, B. N., Rizvi, S. J., Hassel, S., Mueller, D. J., Parikh, S. V., Lam, R. W., Blier, P., Farzan, F., Giacobbe, P., Milev, R., Placenza, F., Soares, C. N., Turecki, G., … Leri, F. (2020). Reverse translation of major depressive disorder symptoms: A framework for the behavioural phenotyping of putative biomarkers. Journal of Affective Disorders263, 353-366. https://doi.org/10.1016/j.jad.2019.11.108

Dunlop, K., Rizvi, S. J., Kennedy, S. H., Hassel, S., Strother, S. C., Harris, J. K., Zamyadi, M., Arnott, S. R., Davis, A. D., Mansouri, F., Schulze, L., Ceniti, A. K., Lam, R. W., Milev, R., Rotzinger, S., Foster, J. A., Frey, B. N., Parikh, S. V., Soares, C. N., … Downar, J. (2020). Clinical, behavioral, and neural measures of reward processing correlate with escitalopram response in depression: A Canadian biomarker integration network in depression (CAN-BIND-1) report. Neuropsychopharmacology45(8), 1390-1397. https://doi.org/10.1038/s41386-020-0688-x

Hassel, S., Sharma, G. B., Alders, G. L., Davis, A. D., Arnott, S. R., Frey, B. N., Hall, G. B., Harris, J. K., Lam, R. W., Milev, R., Müller, D. J., Rotzinger, S., Zamyadi, M., Kennedy, S. H., Strother, S. C., & MacQueen, G. M. (2020). Reliability of a functional magnetic resonance imaging task of emotional conflict in healthy participants. Human Brain Mapping41(6), 1400-1415. https://doi.org/10.1002/hbm.24883

Horman, T., Fernandes, M. F., Tache, M. C., Hucik, B., Mutch, D. M., & Leri, F. (2020). Dietary N-6/N-3 ratio influences brain fatty acid composition in adult rats. Nutrients12(6), 1847. https://doi.org/10.3390/nu12061847

Marshe, V. S., Islam, F., Maciukiewicz, M., Fiori, L. M., Yerko, V., Yang, J., Turecki, G., Foster, J. A., Kennedy, S. H., Blumberger, D. M., Karp, J. F., Kennedy, J. L., Mulsant, B. H., Reynolds, C. F., Lenze, E. J., & Müller, D. J. (2020). Validation study of microRNAs previously associated with antidepressant response in older adults treated for late-life depression with venlafaxine. Progress in Neuro-Psychopharmacology and Biological Psychiatry100, 109867. https://doi.org/10.1016/j.pnpbp.2020.109867

Nogovitsyn, N., Addington, J., Souza, R., Placsko, T. J., Stowkowy, J., Wang, J., Goldstein, B. I., Bray, S., Lebel, C., Taylor, V. H., Kennedy, S. H., & MacQueen, G. (2020). Childhood trauma and amygdala nuclei volumes in youth at risk for mental illness. Psychological Medicine, 1-8. https://doi.org/10.1017/s0033291720003177

Nogovitsyn, N., Souza, R., Muller, M., Srajer, A., Metzak, P. D., Hassel, S., Ismail, Z., Protzner, A., Bray, S. L., Lebel, C., MacIntosh, B. J., Goldstein, B. I., Wang, J., Kennedy, S. H., Addington, J., & MacQueen, G. M. (2020). Aberrant limbic brain structures in young individuals at risk for mental illness. Psychiatry and Clinical Neurosciences74(5), 294-302. https://doi.org/10.1111/pcn.12985

Phillips, J. L., Jaworska, N., Kamler, E., Bhat, V., Blier, J., Foster, J. A., Hassel, S., Ho, K., McMurray, L., Milev, R., Moazamigoudarzi, Z., Placenza, F. M., Richard-Devantoy, S., Rotzinger, S., Turecki, G., Vazquez, G. H., Kennedy, S. H., & Blier, P. (2020). A randomized, crossover comparison of ketamine and electroconvulsive therapy for treatment of major depressive episodes: A Canadian biomarker integration network in depression (CAN-BIND) study protocol. BMC Psychiatry20(1). https://doi.org/10.1186/s12888-020-02672-3

Suh, J. S., Minuzzi, L., Raamana, P. R., Davis, A., Hall, G. B., Harris, J., Hassel, S., Zamyadi, M., Arnott, S. R., Alders, G. L., Sassi, R. B., Milev, R., Lam, R. W., MacQueen, G. M., Strother, S. C., Kennedy, S. H., & Frey, B. N. (2020). An investigation of cortical thickness and antidepressant response in major depressive disorder: A CAN-BIND study report. NeuroImage: Clinical25, 102178. https://doi.org/10.1016/j.nicl.2020.102178

Uher, R., Frey, B. N., Quilty, L. C., Rotzinger, S., Blier, P., Foster, J. A., Müller, D. J., Ravindran, A. V., Soares, C. N., Turecki, G., Parikh, S. V., Milev, R., MacQueen, G., Lam, R. W., & Kennedy, S. H. (2020). Symptom dimension of interest-activity indicates need for aripiprazole augmentation of Escitalopram in major depressive disorder. The Journal of Clinical Psychiatry81(4). https://doi.org/10.4088/jcp.20m13229

Vallati, M., Cunningham, S., Mazurka, R., Stewart, J. G., Larocque, C., Milev, R. V., Bagby, R. M., Kennedy, S. H., & Harkness, K. L. (2020). Childhood maltreatment and the clinical characteristics of major depressive disorder in adolescence and adulthood. Journal of Abnormal Psychology129(5), 469-479. https://doi.org/10.1037/abn0000521

Zhdanov, A., Atluri, S., Wong, W., Vaghei, Y., Daskalakis, Z. J., Blumberger, D. M., Frey, B. N., Giacobbe, P., Lam, R. W., Milev, R., Mueller, D. J., Turecki, G., Parikh, S. V., Rotzinger, S., Soares, C. N., Brenner, C. A., Vila-Rodriguez, F., McAndrews, M. P., Kleffner, K., … Farzan, F. (2020). Use of machine learning for predicting Escitalopram treatment outcome from electroencephalography recordings in adult patients with depression. JAMA Network Open3(1), e1918377. https://doi.org/10.1001/jamanetworkopen.2019.18377

2019

Alders, G. L., Davis, A. D., MacQueen, G., Strother, S. C., Hassel, S., Zamyadi, M., … Hall, G. B. (2019). Reduced accuracy accompanied by reduced neural activity during the performance of an emotional conflict task by unmedicated patients with major depression: A CAN-BIND fMRI study. Journal of Affective Disorders, 257(June), 765–773. https://doi.org/10.1016/j.jad.2019.07.037

Allen, T. A., Lam, R. W., Milev, R., Rizvi, S. J., Frey, B. N., MacQueen, G. M., … Quilty, L. C. (2019). Early change in reward and punishment sensitivity as a predictor of response to antidepressant treatment for major depressive disorder: A CAN-BIND-1 report. Psychological Medicine, 49(10), 1629–1638. https://doi.org/10.1017/S0033291718002441

Belzeaux, R., Fiori, L. M., Lopez, J. P., Boucekine, M., Boyer, L., Blier, P., … Turecki, G. (2019). Predicting Worsening Suicidal Ideation With Clinical Features and Peripheral Expression of Messenger RNA and MicroRNA During Antidepressant Treatment. Journal of Clinical Psychiatry.

Chakrabarty, T., Harkness, K. L., McInerney, S. J., Quilty, L. C., Milev, R. V., Kennedy, S. H., … Lam, R. W. (2019). Childhood maltreatment and cognitive functioning in patients with major depressive disorder: a CAN-BIND-1 report. Psychological Medicine. https://doi.org/10.1017/s003329171900268x

Davis, A. D., Hassel, S., Arnott, S. R., Harris, J., Lam, R. W., Milev, R., … Hall, G. B. (2019). White Matter Indices of Medication Response in Major Depression: A Diffusion Tensor Imaging Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, (Md), 1–12. https://doi.org/10.1016/j.bpsc.2019.05.016

Fonseka, T. M., Pong, J. T., Kcomt, A., Kennedy, S. H., & Parikh, S. V. (2019). Collaborating with individuals with lived experience to adapt CANMAT clinical depression guidelines into a patient treatment guide: The CHOICE‐D co‐design process. Journal of evaluation in clinical practice.

Janzen, T. B., Al Shirawi, M. I., Rotzinger, S., Kennedy, S. H., & Bartel, L. (2019). A pilot study investigating the effect of music-based intervention on depression and anhedonia. Frontiers in Psychology, 10(MAY), 1–13. https://doi.org/10.3389/fpsyg.2019.01038

Ju, C., Fiori, L. M., Belzeaux, R., Theroux, J.-F., Chen, G. G., Aouabed, Z., … Turecki, G. (2019). Integrated genome-wide methylation and expression analyses reveal functional predictors of response to antidepressants. Translational Psychiatry, 9(1). https://doi.org/10.1038/s41398-019-0589-0

Kim, H. K., Tyryshkin, K., Elmi, N., Dharsee, M., Evans, K. R., Good, J., … Feilotter, H. (2019). Plasma microRNA expression levels and their targeted pathways in patients with major depressive disorder who are responsive to duloxetine treatment. Journal of Psychiatric Research, 110(December 2018), 38–44. https://doi.org/10.1016/j.jpsychires.2018.12.007

MacQueen, G. M., Hassel, S., Arnott, S. R., Addington, J., Bowie, C. R., Bray, S. L., … Kennedy, S. H. (2019). The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols. Journal of Psychiatry and Neuroscience, 44(4), 223–236. https://doi.org/10.1503/jpn.180036

McInerney, S. J., Fallahi, A., Edgar, N. E., Ceniti, A. K., Rizvi, S. J., Beder, M., … & Kennedy, S. H. (2019). Suicide-related presentations of homeless individuals to an inner-city emergency department. General hospital psychiatry.

Nogovitsyn, N., Muller, M., Souza, R., Hassel, S., Arnott, S. R., Davis, A. D., Hall, G. B., Harris, J. K., Zamyadi, M., Metzak, P. D., Ismail, Z., Downar, J., Parikh, S. V., Soares, C. N., Addington, J. M., Milev, R., Harkness, K. L., Frey, B. N., Lam, R. W., … MacQueen, G. M. (2019). Hippocampal tail volume as a predictive biomarker of antidepressant treatment outcomes in patients with major depressive disorder: A CAN-BIND report. Neuropsychopharmacology45(2), 283-291. https://doi.org/10.1038/s41386-019-0542-1

Nogovitsyn, N., Souza, R., Muller, M., Srajer, A., Hassel, S., Arnott, S. R., … MacQueen, G. M. (2019). Testing a deep convolutional neural network for automated hippocampus segmentation in a longitudinal sample of healthy participants. NeuroImage, 197(March), 589–597. https://doi.org/10.1016/j.neuroimage.2019.05.017

Sidney H. Kennedy, Raymond W. Lam, Susan Rotzinger, Roumen V. Milev, Pierre Blier, Jonathan Downar, Kenneth R. Evans, Faranak Farzan, Jane A. Foster, Benicio N. Frey, Peter Giacobbe, Geoffrey B. Hall, Kate L. Harkness, Stefanie Hassel, Zahinoor Ismail, Fr, and R. U. (2019). Symptomatic and Functional Outcomes and Early Prediction of Response to Escitalopram Monotherapy and Sequential Adjunctive Aripiprazole Therapy in Patients With Major Depressive Disorder: A CAN-BIND-1 Report. Journal of Clinical Psychiatry, 80(2), 11–12. Retrieved from 10.4088/JCP.18m12202

Storace A, Daniels S, Zhou Y, Kalisch B, Parker L, Rock E, Limebeer C, Lapointe T, Leri F (2019). A study of limbic brain derived neurotrophic factor gene expression in male Sprague-Dawley rats trained on a learned helplessness task. Behav Brain Res 30: 376.

Yrondi, A., Fiori, L. M., Frey, B. N., Lam, R. W., MacQueen, G. M., Milev, R., Müller, D. J., Foster, J. A., Kennedy, S. H., & Turecki, G. (2020). Association between side effects and blood microrna expression levels and their targeted pathways in patients with major depressive disorder treated by a selective serotonin reuptake inhibitor, escitalopram: A CAN-BIND-1 report. International Journal of Neuropsychopharmacology, 23(2), 88–95. https://doi.org/10.1093/ijnp/pyz066

2018

Allega, O. R., Leng, X., Vaccarino, A., Skelly, M., Lanzini, M., Paz Hidalgo, M., … Frey, B. N. (2018). Performance of the biological rhythms interview for assessment in neuropsychiatry: An item response theory and actigraphy analysis. Journal of Affective Disorders, 225(June 2017), 54–63. https://doi.org/10.1016/j.jad.2017.07.047

Allen, T. A., Carey, B. E., McBride, C., Bagby, R. M., DeYoung, C. G., & Quilty, L. C. (2018). Big Five aspects of personality interact to predict depression. Journal of Personality, 86(4), 714–725. https://doi.org/10.1111/jopy.12352

Fonseka, T. M., MacQueen, G. M., & Kennedy, S. H. (2018). Neuroimaging biomarkers as predictors of treatment outcome in Major Depressive Disorder. Journal of Affective Disorders, 233(October 2017), 21–35. https://doi.org/10.1016/j.jad.2017.10.049

Maciukiewicz, M., Marshe, V. S., Tiwari, A. K., Fonseka, T. M., Freeman, N., Kennedy, J. L., … Müller, D. J. (2018). Genome-wide association studies of placebo and duloxetine response in major depressive disorder. Pharmacogenomics Journal, 18(3), 406–412. https://doi.org/10.1038/tpj.2017.29

Maciukiewicz, Malgorzata, Marshe, V. S., Hauschild, A. C., Foster, J. A., Rotzinger, S., Kennedy, J. L., … Geraci, J. (2018). GWAS-based machine learning approach to predict duloxetine response in major depressive disorder. Journal of Psychiatric Research, 99(June 2017), 62–68. https://doi.org/10.1016/j.jpsychires.2017.12.009

Rizvi, S. J., Lambert, C., & Kennedy, S. (2018). Presentation and Neurobiology of Anhedonia in Mood Disorders: Commonalities and Distinctions. Current Psychiatry Reports, 20(2), 6–9. https://doi.org/10.1007/s11920-018-0877-z

2017

Al Shirawi, M. I., Kennedy, S. H., Ho, K. T., Byrne, R., & Downar, J. (2017). Oral Ketamine in Treatment-Resistant Depression. Journal of Clinical Psychopharmacology, 37(4), 464–467. https://doi.org/10.1097/JCP.0000000000000717

Baskaran, A., Farzan, F., Milev, R., Brenner, C. A., Alturi, S., Pat McAndrews, M., … Kennedy, S. H. (2017). The comparative effectiveness of electroencephalographic indices in predicting response to escitalopram therapy in depression: A pilot study. Journal of Affective Disorders, 227(September 2017), 542–549. https://doi.org/10.1016/j.jad.2017.10.028

Farzan, F., Atluri, S., Frehlich, M., Dhami, P., Kleffner, K., Price, R., … Kennedy, S. H. (2017). Standardization of electroencephalography for multi-site, multi-platform and multi-investigator studies: Insights from the Canadian Biomarker Integration Network in Depression. Scientific Reports, 7(1), 1–11. https://doi.org/10.1038/s41598-017-07613-x

Fiori, L. M., Lopez, J. P., Richard-Devantoy, S., Berlim, M., Chachamovich, E., Jollant, F., … Turecki, G. (2017). Investigation of miR-1202, miR-135a, and miR-16 in Major Depressive Disorder and Antidepressant Response. International Journal of Neuropsychopharmacology, 20(8), 619–623. https://doi.org/10.1093/ijnp/pyx034

Lopez, J. P., Fiori, L. M., Cruceanu, C., Lin, R., Labonte, B., Cates, H. M., … Turecki, G. (2017). MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes. Nature Communications, 8(May), 1–12. https://doi.org/10.1038/ncomms15497

2016

Fonseka, T. M., Wen, X. Y., Foster, J. A., & Kennedy, S. H. (2016). Zebrafish models of major depressive disorders. Journal of Neuroscience Research, 94(1), 3–14. https://doi.org/10.1002/jnr.23639

Lam, R. W., Milev, R., Rotzinger, S., Andreazza, A. C., Blier, P., Brenner, C., … Kennedy, S. H. (2016). Discovering biomarkers for antidepressant response: Protocol from the Canadian Biomarker Integration Network in Depression (CAN-BIND) and clinical characteristics of the first patient cohort. BMC Psychiatry, 16(1), 1–13. https://doi.org/10.1186/s12888-016-0785-x

Vaccarino, A. L., Evans, K. R., Kalali, A. H., Kennedy, S. H., Engelhardt, N., Frey, B. N., … Williams, J. B. W. (2016). The depression inventory development workgroup: A collaborative, empirically driven initiative to develop a new assessment tool for major depressive disorder. Innovations in Clinical Neuroscience, 13(9–10), 20–31.

2015

Genetic variation in IL-1β, IL-2, IL-6, TSPO and BDNF and response to duloxetine or placebo treatment in major depressive disorder
Maciukiewicz M, et al. (2015). Genetic variation in IL-1beta, IL-2, IL-6, TSPO and BDNF and response to duloxetine or placebo treatment in major depressive disorder. Pharmacogenomics, 16(17):1919-1929. 

Zebrafish models of major depressive disorders
Fonseka, T. M., Wen, X., Foster, J. A., & Kennedy, S.H. (2015). Zebrafish models of major depressive disorders. Journal of Neuroscience Research, 94(1), 3-14. doi:10.1002/jnr.23639

Fructose: Glucose Ratios—A Study of Sugar Self-Administration and Associated Neural and Physiological Responses in the Rat
Levy, A., Marshall, P., Zhou, Y., Kreek, M., Kent, K., Daniels, S., Shore, A., Downs, T., Fernandes, M.F., Mutch, D.M., Leri, F. (2015). Fructose:Glucose Ratios—A Study of Sugar Self-Administration and Associated Neural and Physiological Responses in the Rat. Nutrients, 7(5), 3869-3890. doi:10.3390/nu7053869

2014 and prior

Restoration of serotonin neuronal firing following long-term administration of bupropion but not paroxetine in olfactory bulbectomized rats
El Mansari, M., Manta, S., Oosterhof, C., Iskandrani, K. S., Chenu, F., Shim, S., & Blier, P. (2014). Restoration of Serotonin Neuronal Firing Following Long-Term Administration of Bupropion but Not Paroxetine in Olfactory Bulbectomized Rats. International Journal of Neuropsychopharmacology, 18(4). doi:10.1093/ijnp/pyu050

A Novel Procedure for Evaluating the Reinforcing Properties of Tastants in Laboratory Rats: Operant Intraoral Self-administration
Levy, A., Limebeer, C. L., Ferdinand, J., Shillingford, U., Parker, L. A., & Leri, F. (2014). A Novel Procedure for Evaluating the Reinforcing Properties of Tastants in Laboratory Rats: Operant Intraoral Self-administration. Journal of Visualized Experiments, (84). doi:10.3791/50956

The Canadian Biomarker Integration Network in Depression (CAN-BIND): advances in response prediction
Kennedy, S. H., Downar, J., Evans, K. R., Feilotter, H., Lam, R. W., Macqueen, G. M., Milev, R., Parikh, S.V., Rotzinger, S. Soares, C. (2012). The Canadian Biomarker Integration Network in Depression (CAN-BIND): Advances in Response Prediction. Current Pharmaceutical Design, 18(36), 5976-5989. doi:10.2174/138161212803523635