Research

Publications


2020

Alders, G. L., Davis, A. D., MacQueen, G., Strother, S. C., Hassel, S., Zamyadi, M., Sharma, G. B., Arnott, S. R., Downar, J., Harris, J. K., Lam, R. W., Milev, R., Müller, D. J., Ravindran, A., Kennedy, S. H., Frey, B. N., Minuzzi, L., & Hall, G. B. (2020). Escitalopram ameliorates differences in neural activity between healthy comparison and major depressive disorder groups on an fMRI emotional conflict task: A CAN-BIND-1 study. Journal of Affective Disorders264, 414-424. https://doi.org/10.1016/j.jad.2019.11.068

Belzeaux, R., Gorgievski, V., Fiori, L. M., Lopez, J. P., Grenier, J., Lin, R., Nagy, C., Ibrahim, E. C., Gascon, E., Courtet, P., Richard-Devantoy, S., Berlim, M., Chachamovich, E., Théroux, J., Dumas, S., Giros, B., Rotzinger, S., Soares, C. N., Foster, J. A., … Turecki, G. (2020). GPR56/ADGRG1 is associated with response to antidepressant treatment. Nature Communications11(1). https://doi.org/10.1038/s41467-020-15423-5

Daniels, S., Horman, T., Lapointe, T., Melanson, B., Storace, A., Kennedy, S. H., Frey, B. N., Rizvi, S. J., Hassel, S., Mueller, D. J., Parikh, S. V., Lam, R. W., Blier, P., Farzan, F., Giacobbe, P., Milev, R., Placenza, F., Soares, C. N., Turecki, G., … Leri, F. (2020). Reverse translation of major depressive disorder symptoms: A framework for the behavioural phenotyping of putative biomarkers. Journal of Affective Disorders263, 353-366. https://doi.org/10.1016/j.jad.2019.11.108

Dunlop, K., Rizvi, S. J., Kennedy, S. H., Hassel, S., Strother, S. C., Harris, J. K., Zamyadi, M., Arnott, S. R., Davis, A. D., Mansouri, F., Schulze, L., Ceniti, A. K., Lam, R. W., Milev, R., Rotzinger, S., Foster, J. A., Frey, B. N., Parikh, S. V., Soares, C. N., … Downar, J. (2020). Clinical, behavioral, and neural measures of reward processing correlate with escitalopram response in depression: A Canadian biomarker integration network in depression (CAN-BIND-1) report. Neuropsychopharmacology45(8), 1390-1397. https://doi.org/10.1038/s41386-020-0688-x

Hassel, S., Sharma, G. B., Alders, G. L., Davis, A. D., Arnott, S. R., Frey, B. N., Hall, G. B., Harris, J. K., Lam, R. W., Milev, R., Müller, D. J., Rotzinger, S., Zamyadi, M., Kennedy, S. H., Strother, S. C., & MacQueen, G. M. (2020). Reliability of a functional magnetic resonance imaging task of emotional conflict in healthy participants. Human Brain Mapping41(6), 1400-1415. https://doi.org/10.1002/hbm.24883

Horman, T., Fernandes, M. F., Tache, M. C., Hucik, B., Mutch, D. M., & Leri, F. (2020). Dietary N-6/N-3 ratio influences brain fatty acid composition in adult rats. Nutrients12(6), 1847. https://doi.org/10.3390/nu12061847

Marshe, V. S., Islam, F., Maciukiewicz, M., Fiori, L. M., Yerko, V., Yang, J., Turecki, G., Foster, J. A., Kennedy, S. H., Blumberger, D. M., Karp, J. F., Kennedy, J. L., Mulsant, B. H., Reynolds, C. F., Lenze, E. J., & Müller, D. J. (2020). Validation study of microRNAs previously associated with antidepressant response in older adults treated for late-life depression with venlafaxine. Progress in Neuro-Psychopharmacology and Biological Psychiatry100, 109867. https://doi.org/10.1016/j.pnpbp.2020.109867

Nogovitsyn, N., Addington, J., Souza, R., Placsko, T. J., Stowkowy, J., Wang, J., Goldstein, B. I., Bray, S., Lebel, C., Taylor, V. H., Kennedy, S. H., & MacQueen, G. (2020). Childhood trauma and amygdala nuclei volumes in youth at risk for mental illness. Psychological Medicine, 1-8. https://doi.org/10.1017/s0033291720003177

Nogovitsyn, N., Souza, R., Muller, M., Srajer, A., Metzak, P. D., Hassel, S., Ismail, Z., Protzner, A., Bray, S. L., Lebel, C., MacIntosh, B. J., Goldstein, B. I., Wang, J., Kennedy, S. H., Addington, J., & MacQueen, G. M. (2020). Aberrant limbic brain structures in young individuals at risk for mental illness. Psychiatry and Clinical Neurosciences74(5), 294-302. https://doi.org/10.1111/pcn.12985

Nogovitsyn, N., Muller, M., Souza, R., Hassel, S., Arnott, S. R., Davis, A. D., Hall, G. B., Harris, J. K., Zamyadi, M., Metzak, P. D., Ismail, Z., Downar, J., Parikh, S. V., Soares, C. N., Addington, J. M., Milev, R., Harkness, K. L., Frey, B. N., Lam, R. W., … MacQueen, G. M. (2019). Hippocampal tail volume as a predictive biomarker of antidepressant treatment outcomes in patients with major depressive disorder: A CAN-BIND report. Neuropsychopharmacology45(2), 283-291. https://doi.org/10.1038/s41386-019-0542-1

Phillips, J. L., Jaworska, N., Kamler, E., Bhat, V., Blier, J., Foster, J. A., Hassel, S., Ho, K., McMurray, L., Milev, R., Moazamigoudarzi, Z., Placenza, F. M., Richard-Devantoy, S., Rotzinger, S., Turecki, G., Vazquez, G. H., Kennedy, S. H., & Blier, P. (2020). A randomized, crossover comparison of ketamine and electroconvulsive therapy for treatment of major depressive episodes: A Canadian biomarker integration network in depression (CAN-BIND) study protocol. BMC Psychiatry20(1). https://doi.org/10.1186/s12888-020-02672-3

Suh, J. S., Minuzzi, L., Raamana, P. R., Davis, A., Hall, G. B., Harris, J., Hassel, S., Zamyadi, M., Arnott, S. R., Alders, G. L., Sassi, R. B., Milev, R., Lam, R. W., MacQueen, G. M., Strother, S. C., Kennedy, S. H., & Frey, B. N. (2020). An investigation of cortical thickness and antidepressant response in major depressive disorder: A CAN-BIND study report. NeuroImage: Clinical25, 102178. https://doi.org/10.1016/j.nicl.2020.102178

Uher, R., Frey, B. N., Quilty, L. C., Rotzinger, S., Blier, P., Foster, J. A., Müller, D. J., Ravindran, A. V., Soares, C. N., Turecki, G., Parikh, S. V., Milev, R., MacQueen, G., Lam, R. W., & Kennedy, S. H. (2020). Symptom dimension of interest-activity indicates need for aripiprazole augmentation of Escitalopram in major depressive disorder. The Journal of Clinical Psychiatry81(4). https://doi.org/10.4088/jcp.20m13229

Vallati, M., Cunningham, S., Mazurka, R., Stewart, J. G., Larocque, C., Milev, R. V., Bagby, R. M., Kennedy, S. H., & Harkness, K. L. (2020). Childhood maltreatment and the clinical characteristics of major depressive disorder in adolescence and adulthood. Journal of Abnormal Psychology129(5), 469-479. https://doi.org/10.1037/abn0000521

Zhdanov, A., Atluri, S., Wong, W., Vaghei, Y., Daskalakis, Z. J., Blumberger, D. M., Frey, B. N., Giacobbe, P., Lam, R. W., Milev, R., Mueller, D. J., Turecki, G., Parikh, S. V., Rotzinger, S., Soares, C. N., Brenner, C. A., Vila-Rodriguez, F., McAndrews, M. P., Kleffner, K., … Farzan, F. (2020). Use of machine learning for predicting Escitalopram treatment outcome from electroencephalography recordings in adult patients with depression. JAMA Network Open3(1), e1918377. https://doi.org/10.1001/jamanetworkopen.2019.18377

2019

Alders, G. L., Davis, A. D., MacQueen, G., Strother, S. C., Hassel, S., Zamyadi, M., … Hall, G. B. (2019). Reduced accuracy accompanied by reduced neural activity during the performance of an emotional conflict task by unmedicated patients with major depression: A CAN-BIND fMRI study. Journal of Affective Disorders, 257(June), 765–773. https://doi.org/10.1016/j.jad.2019.07.037

Allen, T. A., Lam, R. W., Milev, R., Rizvi, S. J., Frey, B. N., MacQueen, G. M., … Quilty, L. C. (2019). Early change in reward and punishment sensitivity as a predictor of response to antidepressant treatment for major depressive disorder: A CAN-BIND-1 report. Psychological Medicine, 49(10), 1629–1638. https://doi.org/10.1017/S0033291718002441

Belzeaux, R., Fiori, L. M., Lopez, J. P., Boucekine, M., Boyer, L., Blier, P., … Turecki, G. (2019). Predicting Worsening Suicidal Ideation With Clinical Features and Peripheral Expression of Messenger RNA and MicroRNA During Antidepressant Treatment. Journal of Clinical Psychiatry.

Chakrabarty, T., Harkness, K. L., McInerney, S. J., Quilty, L. C., Milev, R. V., Kennedy, S. H., … Lam, R. W. (2019). Childhood maltreatment and cognitive functioning in patients with major depressive disorder: a CAN-BIND-1 report. Psychological Medicine. https://doi.org/10.1017/s003329171900268x

Davis, A. D., Hassel, S., Arnott, S. R., Harris, J., Lam, R. W., Milev, R., … Hall, G. B. (2019). White Matter Indices of Medication Response in Major Depression: A Diffusion Tensor Imaging Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, (Md), 1–12. https://doi.org/10.1016/j.bpsc.2019.05.016

Fonseka, T. M., Pong, J. T., Kcomt, A., Kennedy, S. H., & Parikh, S. V. (2019). Collaborating with individuals with lived experience to adapt CANMAT clinical depression guidelines into a patient treatment guide: The CHOICE‐D co‐design process. Journal of evaluation in clinical practice.

Janzen, T. B., Al Shirawi, M. I., Rotzinger, S., Kennedy, S. H., & Bartel, L. (2019). A pilot study investigating the effect of music-based intervention on depression and anhedonia. Frontiers in Psychology, 10(MAY), 1–13. https://doi.org/10.3389/fpsyg.2019.01038

Ju, C., Fiori, L. M., Belzeaux, R., Theroux, J.-F., Chen, G. G., Aouabed, Z., … Turecki, G. (2019). Integrated genome-wide methylation and expression analyses reveal functional predictors of response to antidepressants. Translational Psychiatry, 9(1). https://doi.org/10.1038/s41398-019-0589-0

Kim, H. K., Tyryshkin, K., Elmi, N., Dharsee, M., Evans, K. R., Good, J., … Feilotter, H. (2019). Plasma microRNA expression levels and their targeted pathways in patients with major depressive disorder who are responsive to duloxetine treatment. Journal of Psychiatric Research, 110(December 2018), 38–44. https://doi.org/10.1016/j.jpsychires.2018.12.007

MacQueen, G. M., Hassel, S., Arnott, S. R., Addington, J., Bowie, C. R., Bray, S. L., … Kennedy, S. H. (2019). The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols. Journal of Psychiatry and Neuroscience, 44(4), 223–236. https://doi.org/10.1503/jpn.180036

McInerney, S. J., Fallahi, A., Edgar, N. E., Ceniti, A. K., Rizvi, S. J., Beder, M., … & Kennedy, S. H. (2019). Suicide-related presentations of homeless individuals to an inner-city emergency department. General hospital psychiatry.

Nogovitsyn, N., Muller, M., Souza, R., Hassel, S., Arnott, S. R., Davis, A. D., … McQueen, G. M. (2019). Hippocampal tail volume as a predictive biomarker of antidepressant treatment outcomes in patients with major depressive disorder : a CAN-BIND report. Neuropsychopharmacology. https://doi.org/10.1038/s41386-019-0542-1

Nogovitsyn, N., Souza, R., Muller, M., Srajer, A., Hassel, S., Arnott, S. R., … MacQueen, G. M. (2019). Testing a deep convolutional neural network for automated hippocampus segmentation in a longitudinal sample of healthy participants. NeuroImage, 197(March), 589–597. https://doi.org/10.1016/j.neuroimage.2019.05.017

Sidney H. Kennedy, Raymond W. Lam, Susan Rotzinger, Roumen V. Milev, Pierre Blier, Jonathan Downar, Kenneth R. Evans, Faranak Farzan, Jane A. Foster, Benicio N. Frey, Peter Giacobbe, Geoffrey B. Hall, Kate L. Harkness, Stefanie Hassel, Zahinoor Ismail, Fr, and R. U. (2019). Symptomatic and Functional Outcomes and Early Prediction of Response to Escitalopram Monotherapy and Sequential Adjunctive Aripiprazole Therapy in Patients With Major Depressive Disorder: A CAN-BIND-1 Report. Journal of Clinical Psychiatry, 80(2), 11–12. Retrieved from 10.4088/JCP.18m12202

Storace A, Daniels S, Zhou Y, Kalisch B, Parker L, Rock E, Limebeer C, Lapointe T, Leri F (2019) A study of limbic brain derived neurotrophic factor gene expression in male Sprague-Dawley rats trained on a learned helplessness task. Behav Brain Res 30: 376.

Yrondi, A., Fiori, L.M., Frey, B.N., Lam, R.W., MacQueen, G.M., Milev, R., Müller, D.J., Foster, J.A., Kennedy, S.H. and Turecki, G., 2019. Association between side effects and blood microRNA expression levels and their targeted pathways in patients with major depressive disorder treated by a selective serotonin reuptake inhibitor, escitalopram: a CAN-BIND-1 report. International Journal of Neuropsychopharmacology. https://doi.org/10.1093/ijnp/pyz066

2018

Allega, O. R., Leng, X., Vaccarino, A., Skelly, M., Lanzini, M., Paz Hidalgo, M., … Frey, B. N. (2018). Performance of the biological rhythms interview for assessment in neuropsychiatry: An item response theory and actigraphy analysis. Journal of Affective Disorders, 225(June 2017), 54–63. https://doi.org/10.1016/j.jad.2017.07.047

Allen, T. A., Carey, B. E., McBride, C., Bagby, R. M., DeYoung, C. G., & Quilty, L. C. (2018). Big Five aspects of personality interact to predict depression. Journal of Personality, 86(4), 714–725. https://doi.org/10.1111/jopy.12352

Fonseka, T. M., MacQueen, G. M., & Kennedy, S. H. (2018). Neuroimaging biomarkers as predictors of treatment outcome in Major Depressive Disorder. Journal of Affective Disorders, 233(October 2017), 21–35. https://doi.org/10.1016/j.jad.2017.10.049

Kim, H. K., Tyryshkin, K., Elmi, N., Dharsee, M., Evans, K. R., Good, J., … Feilotter, H. (2019). Plasma microRNA expression levels and their targeted pathways in patients with major depressive disorder who are responsive to duloxetine treatment. Journal of Psychiatric Research, 110(December 2018), 38–44. https://doi.org/10.1016/j.jpsychires.2018.12.007

Maciukiewicz, M., Marshe, V. S., Tiwari, A. K., Fonseka, T. M., Freeman, N., Kennedy, J. L., … Müller, D. J. (2018). Genome-wide association studies of placebo and duloxetine response in major depressive disorder. Pharmacogenomics Journal, 18(3), 406–412. https://doi.org/10.1038/tpj.2017.29

Maciukiewicz, Malgorzata, Marshe, V. S., Hauschild, A. C., Foster, J. A., Rotzinger, S., Kennedy, J. L., … Geraci, J. (2018). GWAS-based machine learning approach to predict duloxetine response in major depressive disorder. Journal of Psychiatric Research, 99(June 2017), 62–68. https://doi.org/10.1016/j.jpsychires.2017.12.009

Rizvi, S. J., Lambert, C., & Kennedy, S. (2018). Presentation and Neurobiology of Anhedonia in Mood Disorders: Commonalities and Distinctions. Current Psychiatry Reports, 20(2), 6–9. https://doi.org/10.1007/s11920-018-0877-z

2017

Al Shirawi, M. I., Kennedy, S. H., Ho, K. T., Byrne, R., & Downar, J. (2017). Oral Ketamine in Treatment-Resistant Depression. Journal of Clinical Psychopharmacology, 37(4), 464–467. https://doi.org/10.1097/JCP.0000000000000717

Allega, O. R., Leng, X., Vaccarino, A., Skelly, M., Lanzini, M., Paz Hidalgo, M., … Frey, B. N. (2018). Performance of the biological rhythms interview for assessment in neuropsychiatry: An item response theory and actigraphy analysis. Journal of Affective Disorders, 225(June 2017), 54–63. https://doi.org/10.1016/j.jad.2017.07.047

Baskaran, A., Farzan, F., Milev, R., Brenner, C. A., Alturi, S., Pat McAndrews, M., … Kennedy, S. H. (2017). The comparative effectiveness of electroencephalographic indices in predicting response to escitalopram therapy in depression: A pilot study. Journal of Affective Disorders, 227(September 2017), 542–549. https://doi.org/10.1016/j.jad.2017.10.028

Farzan, F., Atluri, S., Frehlich, M., Dhami, P., Kleffner, K., Price, R., … Kennedy, S. H. (2017). Standardization of electroencephalography for multi-site, multi-platform and multi-investigator studies: Insights from the canadian biomarker integration network in depression. Scientific Reports, 7(1), 1–11. https://doi.org/10.1038/s41598-017-07613-x

Fiori, L. M., Lopez, J. P., Richard-Devantoy, S., Berlim, M., Chachamovich, E., Jollant, F., … Turecki, G. (2017). Investigation of miR-1202, miR-135a, and miR-16 in Major Depressive Disorder and Antidepressant Response. International Journal of Neuropsychopharmacology, 20(8), 619–623. https://doi.org/10.1093/ijnp/pyx034

Fonseka, T. M., MacQueen, G. M., & Kennedy, S. H. (2018). Neuroimaging biomarkers as predictors of treatment outcome in Major Depressive Disorder. Journal of Affective Disorders, 233(October 2017), 21–35. https://doi.org/10.1016/j.jad.2017.10.049

Lopez, J. P., Fiori, L. M., Cruceanu, C., Lin, R., Labonte, B., Cates, H. M., … Turecki, G. (2017). MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes. Nature Communications, 8(May), 1–12. https://doi.org/10.1038/ncomms15497

2016

Fonseka, T. M., Wen, X. Y., Foster, J. A., & Kennedy, S. H. (2016). Zebrafish models of major depressive disorders. Journal of Neuroscience Research, 94(1), 3–14. https://doi.org/10.1002/jnr.23639

Lam, R. W., Milev, R., Rotzinger, S., Andreazza, A. C., Blier, P., Brenner, C., … Kennedy, S. H. (2016). Discovering biomarkers for antidepressant response: Protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort. BMC Psychiatry, 16(1), 1–13. https://doi.org/10.1186/s12888-016-0785-x

Vaccarino, A. L., Evans, K. R., Kalali, A. H., Kennedy, S. H., Engelhardt, N., Frey, B. N., … Williams, J. B. W. (2016). The depression inventory development workgroup: A collaborative, empirically driven initiative to develop a new assessment tool for major depressive disorder. Innovations in Clinical Neuroscience, 13(9–10), 20–31.

2015

Genetic variation in IL-1β, IL-2, IL-6, TSPO and BDNF and response to duloxetine or placebo treatment in major depressive disorder
Maciukiewicz M, et al. (2015). Genetic variation in IL-1beta, IL-2, IL-6, TSPO and BDNF and response to duloxetine or placebo treatment in major depressive disorder. Pharmacogenomics, 16(17):1919-1929. 

Zebrafish models of major depressive disorders
Fonseka, T. M., Wen, X., Foster, J. A., & Kennedy, S.H. (2015). Zebrafish models of major depressive disorders. Journal of Neuroscience Research, 94(1), 3-14. doi:10.1002/jnr.23639

Fructose: Glucose Ratios—A Study of Sugar Self-Administration and Associated Neural and Physiological Responses in the Rat
Levy, A., Marshall, P., Zhou, Y., Kreek, M., Kent, K., Daniels, S., Shore, A., Downs, T., Fernandes, M.F., Mutch, D.M., Leri, F. (2015). Fructose:Glucose Ratios—A Study of Sugar Self-Administration and Associated Neural and Physiological Responses in the Rat. Nutrients, 7(5), 3869-3890. doi:10.3390/nu7053869

2014 and prior

Restoration of serotonin neuronal firing following long-term administration of bupropion but not paroxetine in olfactory bulbectomized rats
El Mansari, M., Manta, S., Oosterhof, C., Iskandrani, K. S., Chenu, F., Shim, S., & Blier, P. (2014). Restoration of Serotonin Neuronal Firing Following Long-Term Administration of Bupropion but Not Paroxetine in Olfactory Bulbectomized Rats. International Journal of Neuropsychopharmacology, 18(4). doi:10.1093/ijnp/pyu050

A Novel Procedure for Evaluating the Reinforcing Properties of Tastants in Laboratory Rats: Operant Intraoral Self-administration
Levy, A., Limebeer, C. L., Ferdinand, J., Shillingford, U., Parker, L. A., & Leri, F. (2014). A Novel Procedure for Evaluating the Reinforcing Properties of Tastants in Laboratory Rats: Operant Intraoral Self-administration. Journal of Visualized Experiments, (84). doi:10.3791/50956

The Canadian Biomarker Integration Network in Depression (CAN-BIND): advances in response prediction
Kennedy, S. H., Downar, J., Evans, K. R., Feilotter, H., Lam, R. W., Macqueen, G. M., Milev, R., Parikh, S.V., Rotzinger, S. Soares, C. (2012). The Canadian Biomarker Integration Network in Depression (CAN-BIND): Advances in Response Prediction. Current Pharmaceutical Design, 18(36), 5976-5989. doi:10.2174/138161212803523635